Pre-Launch Catalog
Curated Supplements

The LHON Mitochondrial Stack

Every product here has a documented mechanism relevant to LHON — specifically to mitochondrial energy production and optic nerve support. This isn't a random collection. It's 20 years of research distilled into a starting point.

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Mitochondrial Targeted

Every supplement directly supports the mitochondrial pathway affected in LHON — targeting Complex I, the electron transport chain, and optic nerve protection.

Evidence-Backed Dosing

Doses are based on clinical trials and peer-reviewed literature — not label minimums designed to keep costs down.

Form Matters

Ubiquinol, not ubiquinone. R-ALA, not racemic. Active riboflavin-5'-phosphate. The right form can be the difference between working and doing nothing.

The Core Stack

Eight supplements. Every one earns its place.

Mitochondrial Core 900 mg / day

Ubiquinol CoQ10

Directly feeds electrons into the Complex I pathway that fails in LHON — in the pre-converted form your mitochondria can use immediately.

Why it matters ↓
CoQ10 sits at the center of the electron transport chain. Most products use oxidized ubiquinone, which your body must convert before use. Ubiquinol skips that step. Sourcing: 900mg/day, typically 3× 300mg softgels. Look for the Kaneka QH™ logo and third-party COA.
Antioxidant 300 mg / day

R-Alpha Lipoic Acid

Recycles antioxidants in both fat and water environments, crossing the blood-retinal barrier that most antioxidants can't reach.

Why it matters ↓
ALA works in fat-soluble and water-soluble compartments simultaneously. The R-form is the biologically active enantiomer. Most ALA is 50/50 racemic — the S-form competes with R for absorption without providing benefit. R-form only, stabilized.
Neuroprotective 1,000 mg / day

Acetyl-L-Carnitine

Shuttles fatty acids into mitochondria and crosses the blood-brain barrier — neuroprotective effects that standard L-carnitine cannot deliver.

Why it matters ↓
Carnitine is required for fatty acid transport into mitochondria. The acetyl form also crosses the BBB for optic nerve support. Standard L-carnitine does not cross the BBB — for LHON, the acetyl form is non-negotiable. 500mg capsules, 2× daily. Third-party tested for heavy metals.
Retinal Support 12 mg / day

Astaxanthin

The most potent natural antioxidant that crosses the blood-retinal barrier — accumulates directly in retinal and optic nerve tissue.

Why it matters ↓
Astaxanthin uniquely crosses the blood-retinal barrier, with documented retinal and neuroprotective effects at 12mg/day. Must be taken with fat. Natural only — from Haematococcus pluvialis in an oil-based softgel. Synthetic astaxanthin is structurally different and unacceptable.
Complex I Cofactor 400 mg / day

Riboflavin B2

Required cofactor for mitochondrial Complex I — the exact enzyme complex that carries the mutated subunit in LHON.

Why it matters ↓
Without adequate riboflavin, Complex I function is further impaired. The 5'-phosphate form is pre-activated and doesn't require hepatic conversion. Side note: At 400mg/day your urine will be bright yellow — harmless and expected. 400mg/day is at the upper therapeutic range — discuss with your physician.
Macular Protection 24 mg / 5 mg

Lutein + Zeaxanthin

Concentrate in the macula as the retina's primary antioxidant defense — protecting whatever central vision remains.

Why it matters ↓
Lutein and zeaxanthin are the only antioxidants found in the macula, filtering high-energy blue light and neutralizing free radicals. Sourcing: FloraGLO® or Lutemax® sourced, 24mg lutein / 5mg zeaxanthin per serving, softgel for absorption.
ATP Stability 400 mg elemental

Magnesium Malate

Stabilizes ATP at the molecular level and feeds the Krebs cycle via malate — energy input partially independent of Complex I.

Why it matters ↓
ATP exists in the cell as the Mg-ATP complex — without magnesium, ATP can't be properly utilized. Malate is a Krebs cycle intermediate that generates NADH via pathways partially independent of Complex I, providing an alternative energy input when the primary pathway is impaired. Malate form specifically — not oxide, citrate, or glycinate.
Electron Bypass 1–4 mg / day

Methylene Blue

Routes electrons directly around the Complex I break point of LHON — bypassing the exact failure cascade at the source.

Why it matters ↓
MB accepts electrons from NADH and donates them to cytochrome c, bypassing both Complex I and III entirely. At low doses it also increases mitochondrial membrane potential. 120+ years of pharmaceutical history. USP grade only — never industrial or aquarium grade.

Vitamins & Minerals

Whole-food supplements from our Health Through Nutrition wholesale account.

Food Research 3 / day

Complete Eye Health

The only 100% food supplement targeting the eyes — bovine tissue glandulars plus lutein, zeaxanthin, taurine, and vitamins A, C, E from food sources.

Why it matters ↓
Contains bovine eye tissue glandulars, lutein and zeaxanthin, taurine (the most abundant amino acid in the retina), and food-sourced vitamins A, C, and E. For LHON patients, actively protecting remaining vision is priority one. Non-GMO, gluten-free, no synthetic nutrients.
Food Research C Complex
Food Research Vitamin C

C Complex

Food-sourced vitamin C from oranges and acerola — with the cofactors, bioflavonoids, and enzymes that synthetic ascorbic acid leaves out.

Why it matters ↓
100% food-sourced vitamin C is 10× less acidic, gentler on digestion, and delivers real antioxidant cofactors alongside the vitamin. Synthetic ascorbic acid is an isolated molecule. Non-GMO, gluten-free, no synthetics or preservatives.
Food Research D Complex
Food Research Vitamin D3

D Complex

Food-derived D3 with natural cofactors intact — not the synthetic lanolin-derived isolate used in most D3 supplements.

Why it matters ↓
Supports calcium absorption, neurological health, immune resilience, and healthy hormone balance. Foundational for anyone managing a chronic neurological condition. Natural cofactors arrive intact — not stripped by solvent processing. Non-GMO, gluten-free, dairy-free.
Food Research Magnesium Complex
Food Research Food-Form Mg

Magnesium Complex

Whole-food magnesium from organic brown rice — gentler on digestion than mineral salts, with the full food-matrix intact.

Why it matters ↓
For those wanting food-form magnesium as an alternative or complement to the Magnesium Malate in the core stack. Sourced from organic brown rice, not mineral salts (oxide, citrate, glycinate). Required for 300+ enzymatic reactions including ATP synthase. Non-GMO, gluten-free.
Food Research Complete Brain Health
Food Research Cognitive Support

Complete Brain Health

Whole-food glandular formula with bovine brain tissue, pituitary, and medulla glandulars — neuroprotective support for the cognitive load of vision loss.

Why it matters ↓
Combines bovine brain tissue, pituitary and medulla glandulars, selenium, food-sourced vitamin E, and ribonucleic acid (RNA). Supports healthy brain function, relaxation, and emotional well-being. Non-GMO, gluten-free, no synthetic nutrients.
Food Research B Stress Complex
Food Research B Vitamins

B Stress Complex

Food-derived B vitamins from enzymatically processed yeast — no synthetic cyanocobalamin, with all ten essential amino acids naturally present.

Why it matters ↓
B vitamins are essential cofactors for mitochondrial energy production. This whole-food B complex complements the high-dose riboflavin B2 in the core stack without the synthetic isolates found in most B supplements. From enzymatically processed yeast and organic brown rice. Non-GMO, gluten-free.

Choose Your Starting Point

Every stack hits the same failure cascade. The Complete Stack hits more of it, at higher doses.

Entry Point
Basic Stack
~$65 /month
  • Riboflavin B2 — 400mg (active form)
  • Ubiquinol CoQ10 — 100mg
  • Magnesium Malate — 400mg
  • Lutein + Zeaxanthin — 24mg/5mg

Hits Complex I/II directly (B2), the electron shuttle (CoQ10), Krebs cycle support (Magnesium Malate), and retinal protection (Lutein/Zeaxanthin). The highest-leverage interventions per dollar.

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Start with Basic. Build toward Complete. Read the science behind the stack →

Our Sourcing Standards

We evaluate every supplier on the same checklist before it goes on this site.

Third-party tested — COA from an independent lab, not manufacturer self-testing.

Active bioavailable forms — Ubiquinol, R-ALA, riboflavin-5'-phosphate. Not the cheap alternatives.

No proprietary blends — Every ingredient and dose is listed on the label.

GMP certified facility — Current Good Manufacturing Practices, verified.

Clinical dosing — Doses are based on peer-reviewed literature, not RDA minimums.

No unnecessary fillers — No artificial colors, titanium dioxide, or hydrogenated oils in the capsule shell.

Giving Back

The LHON Access Fund

I was diagnosed at 26 and I know what financial pressure looks like on top of vision loss. Not everyone can afford the Complete Stack — or even the Basic one. A portion of every purchase goes directly to providing supplements for newly diagnosed LHON patients who apply for support.

5%
of every purchase
Basic
Stack funded for recipients
Paul
personally reviews each application
Learn about the Foundation →
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Disclaimer: The information on this page is for educational purposes only and does not constitute medical advice. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult your neuro-ophthalmologist or physician before starting any supplement protocol, particularly if you are taking medications or have other medical conditions. LHON Hub may receive a commission on qualifying purchases.